Enterprise Informatics

Applications

Biorepository Portal

The Biorepository Portal (BRP) is a federated web application used to support longitudinal biospecimen collection activities. Using HTTP protocols, it interfaces with downstream data systems, including REDCap and Thermo Scientific's Nautilus LIMS, to provide a single unified interface for data collection and update activities. It leverages the electronic honest broker to ensure that longitudinal data collection is performed in a manner compliant with NCI Best Practices for Biospecimen Resources.

Launch BRP Application

Former Harvest Deployments

former CBTTC Data and Inventory System

The CBTN (Children's Brain Tumor Network) is a multi-institutional cooperative research program dedicated to the study of childhood brain tumors. Previously known as CBTTC (the Children's Brain Tumor Tissue Consortium), the CBTTC Harvest system has been retired effective 21 May 2021.

The ultimate goal of the CBTN is to improve outcomes for children with brain tumors by supporting research on new prognostic biomarkers and therapies. The CBTN is a new paradigm for tissue research, not only collecting all types of childhood brain tumors but additionally performing analysis using cutting edge technologies while freely sharing the data with the scientific community at large to develop new treatments.

If you would like to query the available CBTN specimens and genomic/clinical data, please register for an account on the Kids First Portal via https://portal.kidsfirstdrc.org/explore?id=7bi

To request CBTN specimens and/or data, please complete the CBTN request form at: https://redcap.chop.edu/surveys/?s=A7M873HMN8

former UPenn NTTB Data and Inventory System

The UPenn-CHOP Neurosurgery Tumor Tissue Bank (NTTB), a state-of-the-art brain tumor biorepository, is a collaborative effort between several departments at the University of Pennsylvania (Neurosurgery and Pathology) and the Children’s Hospital of Philadelphia (CHOP). The UPenn NTTB Harvest system has been retired effective 21 May 2021.

Under this collaborative, fresh tumor tissue is collected, processed, and stored for multiple downstream applications. In addition cell lines derived from primary brain tumors are also banked and available for the research community. We hope that this UPenn-CHOP Neurosurgery Tumor Tissue Bank collaborative will facilitate the development of personalized therapies through the characterization of each individual tumor at the genetic, epigenetic and proteomic level.

If you would like to query the available UPenn NTTB specimens and genomic/clinical data, please register for an account on Philadelphia Coaltion For a Cure via https://www.pc4c.org/

To request UPenn NTTB specimens and/or data, please complete the NTTB request form at: https://redcap.chop.edu/surveys/?s=TDREEF77PR

Concussion Genomics Study

The Concussion Genomics Study consists of clinically abstracted data from CHOPs Department of Neurology. This study consists of clinical data abstraction with future laboratory integration possible. The Concussion Genomics study examines and compares child genomics after a concussion event. The EiG is paramount in integrating and maintaining their data using our BioRepository portal as well as an included Harvest instance.

To access the Concussion system,
please contact DBHi's Enterprise Informatics Group at:

e-mail EIGsupport@email.chop.edu

Tobacco Grant Microbiome Study

The Microbiome study is a research study, run in CHOP’s Division of Gastroenterology, Hepatology and Nutrition, comparing the gut Microbiome of subjects with Inflammatory Bowel Disease and the Microbiome of those without. This is a longitudinal study consisting of integrated abstracted clinical and laboratory data. This study will try to better understand the microbiome in healthy pediatric patients and pediatric patients with IBD. It will further investigate the effects of antibiotic exposure, Clostridium difficile (C. difficile) infection, the metabolome, and human genetic variations on microbial populations in these children. The EiG are key players in this data maintenance, management and integration. The EiG is paramount in integrating and maintaining their data using our BioRepository portal as well as an included Harvest instance.

To access the Tobacco Grant Microbiome system,
please contact DBHi's Enterprise Informatics Group at:

e-mail EIGsupport@email.chop.edu

IBD Biorepository

The IBD Biorepository is a collection of samples from multiple studies being run in CHOP’s Division of Gastroenterology, Hepatology and Nutrition. The IBD Biorepository consists of three studies using a common data set to annotate sample collection from these various studies. The IBD BioRepository utilizes the EiG’s BioRepository portal to login these samples and associate the specimen and laboratory data. A “Harvest” instance is in development for this study to allow for cohort discovery.

To access the IBD system,
please contact DBHi's Enterprise Informatics Group at:

e-mail EIGsupport@email.chop.edu

Biorepository Portal Toolkit

Explore our Biorepository Portal Toolkit information page via brptoolkit.com for the toolkit or more information.